Cone Health System

Sarah Simmons, Melissa Morgan, Teresa Hopkins, Kim Helsabeck, Julie Stachowiak, and Mark Stibich; Journal of Infection Prevention 2013, 14:172-174.

57% reduction in MRSA infection rates after 18 months



Impact of a multi-hospital intervention utilising screening, hand hygiene education and pulsed pxenon ultraviolet (PX-UV) on the rate of hospital associated meticillin resistant Staphylococcus aureus infection.




Standard approaches to meticillin resistant Staphylococcus aureus (MRSA) prevention have included hand hygiene and active surveillance. These approaches have shown mixed results. The addition of pulsed xenon ultraviolet (PX-UV) room disinfection for MRSA prevention is a novel approach. This new MRSA prevention method was implemented at an acute care hospital system in Greensboro, NC, USA. An MRSA screening programme was implemented over a six-month period from July 2011 to January 2012 to include all high-risk patients and the majority of surgical patients. A two-week hand hygiene education initiative was implemented in February 2011. The use of PX-UV for terminal cleaning of MRSA patient rooms was also implemented in February 2011. The rates of hospital associated MRSA (HA-MRSA) infections were monitored before and after implementation of all prevention efforts. The HA-MRSA rate decreased at the largest facility in the system by 57%, and for the entire healthcare system by 56% (p=0.001). The two smaller hospitals saw reductions of 51% and 66%, but the results were not statistically significant (p=0.1047 and p=0.2263). Implementing a PX-UV device in conjunction with active screening and hand hygiene was associated with a decrease in HA-MRSA rates. Studies on the individual effect of PX-UV on HA-MRSA rates are warranted.


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Credit pw-editor